Structure-function relationships in biological ion channels
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Structure-function relationships in biological ion channels

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Published by University of Birmingham in Birmingham .
Written in English


Book details:

Edition Notes

Thesis (Ph.D) - University of Birmingham, School of Biosciences, 2003.

Statementby Guy M.P. Coates.
The Physical Object
Pagination240p. ;
Number of Pages240
ID Numbers
Open LibraryOL21684889M

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Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological. In Ion Channels: Methods and Protocols, Second Edition, experts in the field contribute chapters that focus on the strategies, approaches, methods, and protocols for studying a large family of proteins that form ionic channels in the plasma membrane and intracellular membranes of cells. Using practical examples from the cutting-edge current. Brownian and moleculardynamics are thus the only physically valid methods for studying thestructure-function relations in ion channels. Applications of thesemethods to potassium and calcium channels are presented, which illustratethe multi-ion nature of the permeation mechanism in selective biologicalchannels. Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel.

For example, ionotropic glutamate receptors (iGluRs) are formed as tetramers in which a bundle of alpha-helixes spans lipid bilayer (biological membrane) to form a water-filled channel for ion permeation. The channel is gated (opens and closes) when ligand molecules, such as an agonist glutamate, bind to the extra-cellular ligand binding. Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the Format: Kindle.   In this symposium, two experts in the field of structural biology discuss the structure–function relationship of ion and water channels. Eric Gouaux described the structure of the extracellular ligand‐binding domain of ionotropic glutamate receptors (iGluR), and gave an account of the regulatory mechanisms of iGluRs, including.   The combination of molecular biological techniques with electrophysiological recording has permitted the elucidation of structure-function relationships in ion channels. Among the interesting features of voltage-gated channels are voltage-dependent activation and inactivation, toxin binding, conductance, selectivity and regulation.

Simulation approaches to ion channel structure–function relationships - Volume 34 Issue 4 - D. Peter Tieleman, Phil C. Biggin, Graham R. Smith, Mark S. P. Sansom.   Abstract. Voltage-gated calcium (Ca v) channels are miniature membrane transistors that convert membrane electrical signals to intracellular Ca 2+ transients that trigger many physiological events. In mammals, there are ten subtypes of Ca v channel, among which Ca v is the first Ca v α1 to be cloned. Ca v is specified for the excitation–contraction coupling of skeletal muscles, and. valid methods for studying the structure-function relations in ion channels. Applications of these methods to potassium and calcium channels are presented, which illustrate the multi-ion nature of the permeation mechanism in selective biological channels. Key words: Brownian dynamics, ion channels, molecular dynamics, permeation models, Poisson-. Abstract KcsA, a prokaryote tetrameric potassium channel, was the first ion channel ever to be structurally solved at high resolution. This, along with the ease of its expression and purification, made KcsA an experimental system of choice to study structure–function relationships in ion channels.